Activation of Fibroblast Growth Factors by Bioinspired Glycopolymers

Kenichi HATANAKA*, Fumie KURIHARA†, Megumi KUNOU†, Akihiro OKUDA,
Maria Carmelita KASUYA and Mitsuru AKASHI ††

Institute of Industrial Science, The University of Tokyo; 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505 Japan
† Faculaty of Bioscience and Biotechnology, Tokyo Institute of Technology; 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi 226-8501 Japan
†† Faculty of Engineering, Kagoshima University; 1-21-40 Korimoto, Kagoshima-shi 890-0065 Japan

Sulfated poly[2-(glucosyloxy)ethyl methacrylate] (degree of sulfation=1.07, 2.13, 3.86), which was bioinspired glycopolymer, was synthesized by polymerization of 2-(glucosyloxy)ethyl methacrylate followed by sulfation of the obtained polymer. Effects of the sulfated poly[2-(glucosyloxy)ethyl methacrylate]s with various degree of sulfations on the cell proliferation activity of fibroblast growth factors (FGFs). Sulfated poly[2-(glucosyloxy)ethyl methacrylate]s with higher and lower degree of sulfations activated FGF-1 and FGF-2, respectively.


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