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List of Award Articles
Web Release Date:  December 23, 2009
19-32

Catalytic Enantioselective Alkylation and Arylation of Aldehydes by Using Grignard Reagents
Y. Muramatsu, S. Kanehira, M. Tanigawa, Y. Miyawaki, and T. Harada*
[Full Text PDF(J-STAGE)]  [Supporting Information]

Grignard reagents can be used in enantioselective alkylation and arylation of aldehydes by using chiral titanium(IV) catalysts in the presence of titanium tetraisopropoxide. The reaction proceeds with a low catalyst loading, exhibiting high enantioselectivity for various Grignard reagents and aldehydes.




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