Activation of Fibroblast Growth Factors by Sulfated Carboxymethyldextran

Kenichi HATANAKA*, Megumi KUNOU and Kengo SHIMIZU

Institute of Industrial Science, The University of Tokyo; 7-22-1 Roppongi, Minato-ku, Tokyo 106-8558 Japan
Department of Biomolecular Engineering, Tokyo Institute of Technology; Nagatsuta-cho, Midori-ku, Yokohama-shi 226-8501 Japan

Dextran was carboxymethylated and sulfated to prepare sulfated CM-dextrans with various degree of substitution in order to investigate the interaction between acidic polysaccharides and fibroblast growth factors (FGFs). It was shown that CM-dextran with low degree of sulfation slightly activated FGFs. It was concluded that the degree of anionization was more effective than the kinds of sugars or linkages on the activation of FGFs.

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