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Development of Dimensionally Controlled Polymer Materials by Use of Self-assembly Based on Weak Interactions

Posted: Dec. 07, 2015

Award Recipient: Prof. Mitsuru Akashi Graduate School of Engineering, Osaka University

Generally interactions such as hydrogen bonding, electrostatic,
hydrophobic interactions and others play important roles for structure and
mechanical properties in both synthetic and naturally occurring polymers. Since
week interactions such as van der Waals and hydrophobic interactions reveal their
character strongly in polymer system comparing with low molecular weight
compounds, we can use them for design and creation of functional polymer
materials. In my lecture, 1) I talk on complex formation of i-PMMA with
s-PMMA and poy-L-lactide with poly-D-lactide by van der Waals interaction with
using Layer-by-Layer technique, and their application to stereoregular free radical
template polymerization of MMA. And, 2) the formation of nano-particles derived
from poly-γ-glutamic acid bearing phenyl alanine ethylester by use of hydrophobic
interaction occurred in an aqueous system have been established and applied for
antigen proteins DDS (vaccine) . Finally, 3) 3D living tissues with manipulated
cells have been accomplished by use of affinity interaction between so-called ECM
proteins for regenerative medicine and human tissue models instead of animal
experiments.